Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells

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Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells.

Murine norovirus (MNV) is presently the only member of the genus Norovirus in the Caliciviridae that can be propagated in cell culture. The goal of this study was to elucidate the proteolytic processing strategy of MNV during an authentic replication cycle in cells. A proteolytic cleavage map of the ORF1 polyprotein was generated, and the virus-encoded 3C-like (3CL) proteinase (Pro) mediated cl...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2006

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.00532-06